Properties in Cardiovascular and Pleiotropic

Author(s): Sasha James*

Cardiovascular illnesses continue to be the major cause of death globally.
Coronary atherosclerosis is caused by a complicated interaction of
metabolic and inflammatory mechanisms. Atherogenesis is caused
by apolipoprotein B containing lipoproteins, specifically Low-Density
Lipoprotein Cholesterol (LDL-C), according to mechanistic and genetic
data. Statins, also known as 3-hydroxy-methylglutaryl coenzyme A
reductase inhibitors, reduce cholesterol production while also lowering
blood LDL-C and triglyceride levels. The efficacy of statins for both
primary and secondary prevention of Coronary Heart Disease (CHD)
has been proven in clinical trials. Statins are thought to have both LDL-
C-dependent and LDL-C-independent (or pleiotropic) effects. Clinical
studies demonstrate statin benefits in conditions not obviously linked to
LDL-C, however some of the outcomes may be due to direct cholesterol
lowering.

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