Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Navrangpura, Ahmedabad, Gujarat, India
Publications
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Research Article
Formulation Development and Evaluation of Vancomycin HCL Nanoparticles for the Treatment of Bacterial Meningitis
Author(s): Mansi Athalye* and Anuj Patel
Abstract
The drugs which are used for the treatment of are bacterial meningitis are
ampicillin, gentamycin, cefotaxime, and vancomycin HCL, where vancomycin
HCL is broad spectrum antibiotic. There are various Nano particulate drug delivery
systems such as dendrimers, lipoic nanoparticles, inorganic nanoparticles
and polymeric nanoparticles capable of incorporating the therapeutic drugs or
imaging agents with the effective drug targeting at required site in the body.
The effective treatment and diagnosis of various CNS diseases is restricted by
Blood–Brain Barrier (BBB) which inhibits almost all the macromolecular drugs
as well as small-molecule drugs to permeate through brain. The direct drug
delivery of drugs to brain may indicate higher therapeutic activity to toxicity
ratio as that of systemic drug delivery. The intranasal drug delivery is the noninvasive..
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