Department of Clinical Pharmacist, Ritsumeikan University, Kyoto, Japan
Publications
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Commentary
Dosing Guideline Variation Evaluation and Consequences
Author(s): Kyoichi Katayama*
Abstract
Neonatal bacterial sepsis is a major common disease that threatens the life of
newborns, not only has a high incidence rate but also has a high mortality. After
the diagnosis of neonatal sepsis, the rational use of antibiotics is the primary
treatment measure. In cases where antibiotics are indicated, treatment should be
based on the dosing guidelines. Standard dosing guidelines are systematically
developed statements to help practitioners or prescribers to make decisions
about the appropriate treatment for specific clinical conditions. Even though
guidelines are available for the optimal management compliance is a problem
and varies from country to country due to significant variation. Such variations in
current dosing recommendations and non-compliance may result in selection of inadequate doses or inappropriate dosing intervals for the treatment ultimate re..
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