Clinical Manager, Pharmacy Services, St. Vincent’s Medical Center Riverside, Jacksonville, FL, USA
Publications
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Original Article
The Evaluation of Patient Outcomes with and without the Use of
Alvimopan
Author(s): Calvin Tucker*, Gerard Woolyhand and John Baker
Abstract
Background: Alvimopan is a novel peripheral mu receptor antagonist that is indicated for preventing post-operative ileus in patients undergoing abdominal surgery or bowel resection. Alvimopan has specific administration requirements when given to patients to prevent post-operative ileus. Methods: A retrospective cohort of 80 patients was identified by a primary procedure of colon/rectal surgery. The primary outcome assessed was rate post-operative ileus. To control for acuity difference, the random sample of 80 patients were stratified by Charlson score using Optum One software. The patients were randomly selected reviewing patients who received or did not receive alvimopan. Results: The rate of post-operative ileus with alvimopan 33.3% compared to 32.5% without alvimopan was comparable (p=0.45). The 30-da..
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