Faculty of Science, Taif University, Al-Hawyeia, KSA
Publications
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Original Article
Genotoxic and Hypogonadism Effect of Triclosan Treatment and the Mitigating Effect of Vitamin E in Male Albino Mice
Author(s): Nahed A Hussien* and Hamida Hamdi
Abstract
The widely used antimicrobial compound, triclosan (TCS), causes various harmful impacts to human. The present study was aimed to evaluate the genotoxic and antiandrogenic potential of TCS represented by DNA damage (Comet assay), histopathological and testicular hormonal evaluations. Moreover, the study was aimed to assess the protector role of vitamin E (Vit E) pre-treatment in testes of albino male mice. TCS was injected IP at dose level (15 mg/kg) for 2 consecutive days. Other group was orally administrated with Vit E (50 mg/kg) just before TCS injection. Mice were sacrificed after 24 hr from the last treatment. Testicular tissues were used for molecular, histopathological evaluations and different testicular hormones (testosterone, FSH and LH) determination. The present study reports the genotoxic effect of TCS because of a significant increase in tail length, %DNA in tail and tail..
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